T T T C C G C T T A C C A G T G A G C A C T C C A T C A T A G C G T T G G C C C A G G C G T C C A C A C T C A G AG C T G G A C T A A G T T T T C A G G C C C A C G G C A A C A G C T C C T G A G T A A G G G T A C G G C T AG C C A T A TT A A C T A A T A A A G A G C C G T T G G G T G G A A C A C G C C G TG T C A G T G T C T T A C A G G A A A A T G G G C T T C T C C A C G G C A C G C C G G G A C A A G C A A A G G C T T C T A T A C G T A G C G T A C A G T G AT A A G G A C A C T T AC A T G C G C G G C T A A T C A A T G C G T T G A A T C A C T C T T G T A C C T T A G G A G A T A T C A A G T T T C A G G T T T A T T A A C C T A C C G A T T T C T C T A C A T CA G G C T C T T A T CT C C C C C T A C G G C T C A A A G G T C G T T C G T G A G G A G G G C T G C C A G C A A A T G C C C C C A A A G C G A A A G C C CC G T T A A G C C G A C C T T C A A G T G A C G C T G T A G T A T C G T T T A A C G G C G A T A A C G C C G G G T C C C T T T C G G G C C A C A A C G C G A A C T A C A C T A G A A G T C G C T A T T C G G C T C CA A G T A A C G T C A C C C C C T G T T T A C A C A C C G T T T A A C C G A G A C T TT G T C GA C C G T C C G G A G G C T G C A T A C T C G C T T G A A G G A C A G G T G A A T T G G T G A C T C G C C C C T C G G G C T C A A A A T G C A T G C T C T G A G C T A G A G A C C T G A T A T C C G C C G C A T C T C C C G T C G T C T A T G G T T C C T A C T G T G A A T A C C C T A C T T T C G T C C G T A A C A C C C G G T G G C T G A G T C A T G C T C T T G C G G T G G G A G C G C C C A C G A T T A T C G T A A A T CT T C T A G C CG A G T T A A A G T A T C G C C A G T A A T C G A T G G G C A A T G G G G C A A G G G G C A T G G A G A T C T G G C G G T A A CT C A GT A T C A T T T T A G C A T A T G A G T C G T A T T G C G A C T A A T T T A G C C A G G T G T T T A G G G C T T G T T G A T C G C G G C T A G GG G C A A T A G A G G T C G C C A A G C G G A G T C C C T A T G C T T T A C A C C TT C A G G C T C T

ACGTACATT TGT GGT GC ATA AC GG CG AG AT TAT TC AG TG GC C G GC GC AACCG AT GA GC GCGC CC AC GT CCAA GC AG CA GTT CG GC CTTA GGGGT AA TC GATGTCA CT GG AC GA CA CG ATT TCA TAGGGCTA TA

ATAGAGCGAGCG TAACAAACT TC T GATCCT GAG C TTACGC AGA C GATAGCC AT GTTGCCGGGCCC TGCCATCTCACA GAGAGATGTTTC T C A C CGGCAGACCAAA GT G G CCT A CG G G ATCCACCAAATT GGTGCCGTACCG GTCGCATGAGCA GTAGAGTCCCTC AACCCGGGACTA AC G T G A T GG CT CCT C T G C G A TACGAACGCATT CT G TTCGTACCCGGA TTCGGGATCAGA TAACTGGTCTCA AGTGATCGATCG T T C A CTAGAATTGATG TGCACAGCGGCA CACTGAGCCAGA G T T AA CGGTCTCTGAGT C GGC T ACAGACCTGATA AGAGCCGGCACA TTATCTCGCTTC TC C G TAGATTTTATCG ACGAGCGGGTTG C T G GA C A A G GT CT A ACATCAGCAATC GCTCGAAAGTTT CTA C G TT CG ATTCACGAGAAA CTACCCGCCACT TAACCTCTAGAC AAGGGCCTCAGG G CTA TT CTACGAGTTGTT ACTGCAACCCCT AGCGCTTTAGTG TG G G T CTTA G TG CA A CT T TT A C A G CCGGG C C AG ATGCTACGGTAC TTTTGAGACCAA ATTCGCCTAGGT G A A A AGCGAAGATGGA GCACCCTAGAGC TAACACCGCGCG C A C ATATCATTGCTT AGCCC GGAG TCCAGAGATCCT AAACAACGCAAG GCG G G TC T TT G T

A GC T G A T A C G A A GA TC G AC G AC G G CA C CC G T TT TT T TT T A G CA G TG TT T T TC G T A AA C GT AC T C C G CT A AT A CA TG A G AA G TG TC C AT G C AG A C C TC AC G AC C TC C T GT A CC C G C CA CC AA A T G AA T AC AC C GT A GA A AA G G AT A AA CC T TGGTGTTGT C AA CG T C T CA AA T G T C AA AG C C CC TC C A A AT A A TC G GA C TC TT AG GG C C C AT G AC AC G GA C GG C GA T GG A GC A C G A GC TA G GA GATGG T A C ATCGCTATT G C CG GGCCG AA T G GA C T TT CT AT A TA G CA A C G GT A TT TT T AC G G A GG AA CA G C A CA T A GC A C A CT TC T GT TG C A GG G GG AC T CA T A AC ACGTA G C A G GC CG G CC T T TC T AA C AT T TC AC A CC A G A CT GC T AC T AG A CG G G GT G GG A AA GA A T GA AC A CT T TT C T G G T GA A AG A AA AT GG CG AA T C T G G CA A CC C CA TG G AA T C T CA AC AA GA C C CA T CG C A TA A AG C TC AA G T G GC G G GC G T G TA T CG CG C TA C

We're hiring!

Join FinalDose

Build the DNA-triggered cancer cure. Small team, hard problems, real wet-lab loop.

REQ-01/Reports to Head of Biology/London/On-siteOpen

Biology — Delivery

FinalDose's platform requires delivery solutions tailored to each therapeutic indication. You will lead delivery engineering across multiple administration routes, optimizing lipid nanoparticle formulations for tissue-specific targeting and therapeutic efficacy. Your work will bridge in vitro formulation development with in vivo validation and ultimately support technology transfer for GMP manufacturing. This is a critical role linking our construct engineering with clinical-stage drug products.

Responsibilities

Lead LNP delivery engineering across multiple administration routes, including local, systemic, and inhaled formulations
Develop and optimize LNP formulations with full physicochemical characterization (DLS, encapsulation efficiency, zeta potential)
Perform in vitro delivery optimization and hand off validated formulations to the in vivo team for animal studies
Support CMO/CDMO selection and technology transfer for GMP-grade manufacturing
Collaborate with biology teams to evaluate delivery efficiency using functional readouts (editing efficiency, reporter assays) in cell lines and primary cells

Required

Ph.D. in pharmaceutical sciences, drug delivery, biomedical engineering, or chemical engineering
3–5+ years of hands-on experience with lipid nanoparticle formulation
Demonstrated expertise in at least two of the following: mRNA-LNP encapsulation and delivery, tissue-targeted delivery (SORT technology or ionizable lipid screening), inhaled or pulmonary drug delivery
Experience with microfluidic mixing and formulation scale-up
In vitro delivery characterization in cell lines and primary cells

Preferred

Experience with intravesical or local drug delivery
CMC or technology transfer experience with a CDMO
Air-liquid interface (ALI) culture and aerosol delivery expertise
Awareness of GMP manufacturing processes and requirements

Applyfounders@finaldose.ai

>Delivery Scientist

Responsibilities

Required

Preferred